UAMC Chosen for Drug Study

New drug may improve

function after acute

spinal cord injury

The University of Arizona Medical Center in Tucson is one of 60 trauma centers in the United States, Canada and Europe selected to conduct a clinical trial of a new investigational drug that could help people with acute spinal cord injuries (ASCI) experience less spinal cord damage and have improved function.

Researchers are evaluating the safety and efficacy of an investigative new drug called SUN13837 to determine whether it can protect and regenerate the spinal nerves in ASCI patients. To be considered for the study, a participant must have suffered a spinal cord injury within 12 hours prior to receiving the first dose of the medication and be available for daily dosing for 28 consecutive days.

UAMC is the only Level I Trauma Center in the Southwest involved in the two-year study. UA Department of Surgery surgeons Randall Friese, MD, associate professor, Division of Trauma, Critical Care, Burn and Emergency Surgery, and Rein Anton, MD, PhD, assistant professor, Division of Neurosurgery, are leading the study.

Acute spinal cord injury occurs in 13,000 to 15,000 individuals in the United States each year; well over half of the cases experience quadriplegia. The estimated lifetime cost of acute spinal cord injury for a 25-year-old patient is in the millions of dollars.

At present, no drug has been approved by the U.S. Food and Drug Administration or Health Canada to treat the paralysis and sensory loss that occurs after ASCI. The study is sponsored by Asubio Pharmaceuticals, Inc., a Daiichi Sankyo Group Company.

The study is designed as a collaboration among trauma centers and rehabilitation and spine centers. Typically, these centers have not participated together in clinical programs and it is hoped this study will lead to further cooperation in future clinical programs. UAMC patients in the study will be followed at HealthSouth Rehabilitation Institute of Tucson.